Most iPads work based on the touch panel. If I use the 'Bamboo Paper' app to jot notes, it supports Palm rejection. For example, I used Wacom Bamboo Fineline pen. The new breed of pen for iPad could tell the tablet to ignore the touch of the palm when it is used with the right applications. Normally when you write on the iPad, you might rest your palm on the surface but iPad normally will take it as a touch. Its pen has a button to switch between modes (pen vs eraser) and the high-end model has pressure sensor which is essential for artists. Wacom is the leader in the stylus market. First you open the document with an app, then you annotate freehand on it to highlight key points and jot down short notes. You need to have a large surface to write on. There are more grounds for us to focus on the support of iPad for it has better wireless casting and better tools.

If you are in a meeting/class, you could use an iPad, an AppleTV and a pen to present and highlight things to the audience.

If you want higher accuracy, you need to have a pen. PDF or PPT) on your iPad, you could do it with your finger. If you want to draw/annotate freehand on a document (e.g.

Why do you need a pen to go with your iPad?

Bamboo paper apple pencil